I've got some new evidence:
1st
Before editing rules in Hazel, I stop Hazel. Otherwise, I am totally running out of memory, and can hardly do anything. After closing the System Preferences, I start Hazel again. This is somehow working, but RAM usage after opening the Hazel Pref pane is still somewhere about 5 or even 7 GB.
2nd
Hazel was running fine this morning. After a certain time, even when there hasn't been any action and Hazel didn't have anything to do, I see in the Activity monitor that there are 68 (!) "hazelworkers" active. RAM usage in average between 6 and 30 MB, one of them about 300 MB, but the peak was just over 5 GB! See my screenshot from the Activity Monitor:

Even after stopping Hazel, the "hazelworkers" are still active and don't free any RAM. The only way is to quit the processes.
Could this be an issue under Mac OS Lion? I had almost the same number and kind of rules running before under Mac OS Snow Leopard, and never faced such problems…
I would be very appreciated if there is a way to get this sorted out.
EDIT: Hazel is still stopped, but the remaining "hazelworkers" are using around 100 MB of RAM each now.